Table 2.

1,2,4-oxadiazol-3-yl benzoic acid derivatives in RAR α, β and γ transactivation assays.^a

Compd	X	β EC50 nMa	α EC50 nMa	Fold selectivity for β over αb	γ EC50 nMa	Fold selectivity for β over γb	cLogPd
ATRA	-	1.9	1.2	0.9	0.6	0.5
5		1.5	18c	28	12	19	5.1
8		4200	18	17	0.0043	0.0041	7.2
9		1.4	4	3	2.8	2.1	7.2
10		1.9	26	11	13	5.6	5.3
11		2.5	19	5.3	7.6	2	5.3
12		3.4	30	6.3	9	2	5.8
13		11	114	83	10	7.5	4.1

^a–dSee Table 1.