Table 6.
Species | Clearance mL/h/kg | Volume distribution ss mL/kg | t1/2h | Tmax h | Fraction absorbed % |
---|---|---|---|---|---|
rata | 3.7 | 0.41 | 1.4 | 1.7 | 80b |
dogc | 1.1 | 0.23 | 2.5 | 1.0 | 45 |
iv dose 0.5 mg/kg administered in 4% DMSO, 38% PEG-400, 58% (0.9%) NaCl. Oral doses of 1, 3 and 10 mg/kg prepared in 8% ethanol and 92% PEG-400.
Based on mean of data obtained at 1, 3 and 10 mg/kg oral dose levels in comparison to iv dose of 0.5 mg/kg.
iv dose 0.5 mg/kg administered in 2% DMSO, 98% aqueous hydroxypropyl-β-cyclodextrin (22.5% w/v). Oral dose 3 mg/kg administered in 3% DMSO, 97% aqueous hydroxypropyl-β-cyclodextrin (22.5% w/v). For assay description a,csee Ref. 4.