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. 2019 Apr 15;29(8):995–1000. doi: 10.1016/j.bmcl.2019.02.011

Table 6.

Pharmacokinetic data for Compound 10 in Rat and Dog.12

Species Clearance mL/h/kg Volume distribution ss mL/kg t1/2h Tmax h Fraction absorbed %
rata 3.7 0.41 1.4 1.7 80b
dogc 1.1 0.23 2.5 1.0 45
a

iv dose 0.5 mg/kg administered in 4% DMSO, 38% PEG-400, 58% (0.9%) NaCl. Oral doses of 1, 3 and 10 mg/kg prepared in 8% ethanol and 92% PEG-400.

b

Based on mean of data obtained at 1, 3 and 10 mg/kg oral dose levels in comparison to iv dose of 0.5 mg/kg.

c

iv dose 0.5 mg/kg administered in 2% DMSO, 98% aqueous hydroxypropyl-β-cyclodextrin (22.5% w/v). Oral dose 3 mg/kg administered in 3% DMSO, 97% aqueous hydroxypropyl-β-cyclodextrin (22.5% w/v). For assay description a,csee Ref. 4.