Table 1.

Variation of benzyl substituents.

Compound		Kd ± SDa (µM)	IC50 ± SDb (µM)
3		29.3 ± 5.8	67.9 ± 3.5
4		2.7 ± 0.1	nd
5		2.7 ± 0.1	4.6 ± 0.3
6		29.2 ± 0.9	nd
7		7.6 ± 2.5	11.4 ± 4.2
8		1.2 ± 0.1	2.1 ± 0.8
9		1.5 ± 0.1	1.3 ± 0.2
10		6.6 ± 2.0	8.6 ± 4.2
12		46 ± 1.7	nd

^aK_d: SPR binding affinity, values are mean ± standard deviation from n = 2–10 separate experiments.

^bIC₅₀: compound concentration that reduces actin bundling by 50%, values are mean ± standard deviation.