Skip to main content
. 2019 Mar 8;13:30. doi: 10.3389/fnana.2019.00030

Figure 2.

Figure 2

Effect of RXFP3 depletion in the MS/DB of adult, floxed-Rxfp3 mice on learning and long-term reference memory in the Morris Water Maze (MWM) test. (A) Mice with RXFP3 depleted from the MS/DB were less likely to adopt a spatial search strategy across the acquisition days, relative to eGFP-injected control mice [treatment: OR: 0.56, 95% CI (0.33; 0.96), p = 0.034]. (B) On the probe day, AAV(1/2)-eGFP mice spent significantly more time in the target quadrant relative to the other quadrants in the first 30 s bin, whereas, AAV(1/2)-Cre-IRES-eGFP mice did not spend more time in the target quadrant relative to the other quadrants in the same 30 s period (one-way analysis of variance (ANOVA), Bonferroni post-hoc analysis, **p < 0.01, ***p < 0.001, ****p < 0.0001, n = 8–12 mice per group). (C) Examples of swim tracks during the first 30 s on probe day of three representative (upper) AAV-eGFP injected mice (GFP1–3) and (lower) AAV(1/2)-Cre-IRES-eGFP mice (Cre1–3).