Table 1.
Characteristics of the selected smart devices and health apps (taken from respective product webpages)
| Device | Company | Target population/indication | Description/purpose of the device | Mechanism of action | Additional features | Associated apps | Associated software |
|---|---|---|---|---|---|---|---|
| RebiSmart® [www.RebiSmart.com] | Merck KGaA | MS | Individually adjustable electronic injection device to administer a pre-set dose of Rebif (interferon β-1a) to reduce the frequency of relapses in people with relapsing forms of MS | Administers Rebif subcutaneously, collects and stores data, and sends the information wirelessly to the MSdialog server | Allows patients to self-inject; records an accurate and objective dosing history, including the date, time, and dosage of every injection; hidden needle, multidose cartridge and adjustable comfort settings; sends injection reminders | MS Dialog App | MSdialog |
| BETACONNECT™ [www.betaseron.com] | Bayer AG | MS | Autoinjector that delivers Betaseron (interferon β-1b) to reduce the frequency of relapses in people with relapsing forms of MS | Delivers Betaseron, and pairs with myBETAapp via Bluetooth® to deliver real-time data (such as injection date, time, speed, and depth) with the BETA nurse and HCPs | Sends injection reminders; adjustable injection depth and speed; hidden needle; smooth, quiet injection; automatic needle retraction; visual and audible end-of-dose indicator; simple to unload | myBETAapp | BETACONNECT™ navigator |
| Proteus Discover [www.proteus.com] | Proteus Digital Health, Inc | Multiple indications | An ingestible pill that provides objective confirmation of adherence to oral medications. Approved with aripiprazole in schizophrenia, bipolar disorders, and depressiona | Proteus Discover is activated by taking medication with an ingestible sensor. The sensor transmits a signal from the stomach to a patch worn on the torso. A digital record is sent to the patient’s mobile device and then to the Proteus cloud where it can be accessed by HCPs | Battery-powered adhesive sensor; the patch on the torso also records patient’s heart rate, temperature, activity, and rest patterns | Discover | Discover Portal |
| SmartInhaler™ [www.smartinhaler. | Adherium North America, Inc | Asthma/COPD | Medication sensors that clip around a standard inhaler and automatically send usage data to a mobile app or PC via Bluetooth® | Contains sensors that attach to existing inhalers and record when medication is taken. These sensors automatically send usage data to a mobile app or PC via Bluetooth® | Tracks medication use; sends medication reminders | SmartInhaler™ app | SmartInhalerlive™ |
| Propeller [www.propellerhealth. | Propeller Health | Asthma/COPD | Attaches to the top of the canister of a standard inhaler. Records the location, date, and time of inhaler actuations | Records use of rescue inhaler to provide a summary of potential triggers. Connects with health care providers to share data | Reminders to take medication provided; provides useful geospatial information of asthma attacks to patients; provides personalized daily asthma forecasts | Propeller mobile app | Propeller web app |
Note:
a
Indicated in adults for the treatment of schizophrenia, bipolar 1 disorder, and as adjunctive treatment for major depressive disorder.
Abbreviations: HCP, health care professional; MS, multiple sclerosis; PC, personal computer.