Table 3.

Study details and results from all identified studies of BETACONNECT™/myBETAapp (adherence, clinical outcomes and health care resources use)

Study name	Study objective	Study design	Indication	Sample size	Follow-up period	Key results
Kleiter et al (2017)32	To investigate adherence to therapy, satisfaction, and functional health status among patients treated with interferon β-1b using the BETACONNECT™ autoinjector	Prospective, observational	RRMS	151	24 weeks	• Patient age (mean ± SD) was 41.2±11.5 years • Adherence of ≥80% declined from 72.0% (week 4) to 67.3% (week 12) and 57.9% (week 24) for patients with a least one data readout and from 81.1% at week 4 to 86.7% at week 12 to 80.5% at week 24 for patients at the respective visit • Compliance was 86.3% at week 4, 91.9% at week 12, and 92.9% at week 24 • Age tended to be a predictor of persistence at 24 weeks with patients ≥40 years being more likely to still use the BETACONNECT™ at follow-up visits (OR =1.047, 95% CI 1.003, 1.093) • Treatment-naive patients showed overall higher persistence (OR =12.246; 95% CI 2.191, 68.457)
Patti et al (2017)33	To measure adherence in patients with RRMS or CIS who were treated with interferon β-1b using BETACONNECT™	Multicenter, prospective, single-arm, observational	RRMS and CIS	498 (474 RRMS and 26 CIS)	24 weeks	• Patient age (median) was 44 years • Adherence (defined as completing ≥80% of prescribed injections) was assessed at baseline, week 4, week 12, and week 24. Median adherence remained stable between 93.9% and 95.4% at all visits • Higher adherence was associated with male gender, existing concomitant disease, shorter disease duration, higher SDMT score and higher satisfaction with the myBETApp
Rametta et al (2017)34	To assess adherence to interferon β-1b therapy in patients who are using the BETACONNECT™ autoinjector	Multicenter, prospective, single-arm, observational	RRMS	89	6 weeks	• Patient age (mean) was 52 years; majority (77.5%) of patients aged ≥45 years • Mean adherence rate was 97.6% (SD 9.0%) • 95.5% of patients reached ≥80% adherence

Abbreviations: CIS, clinically isolated syndrome; OR, odds ratio; RRMS, relapsing-remitting multiple sclerosis; SDMT, Symbol Digit Modalities Test.