Table 1.
MIC90 of apramycin in comparison with gentamicin and amikacin against clinical isolates of Enterobacteriaceae and A. baumannii isolated between 2014 and 2017
| MIC90 (mg/L) |
||||
|---|---|---|---|---|
| Species | No. | APR | GEN | AMK |
| Enterobacteriaceae (all) | 1132 | 8 | >64 | >64 |
| Escherichia coli | 250 | 8 | >64 | >64 |
| Klebsiella pneumoniae | 372 | 4 | >64 | >64 |
| Enterobacter spp. | 179 | 4 | >64 | >64 |
| Morganella morganii | 37 | 8 | >64 | 4 |
| Citrobacter freundii | 131 | 8 | >64 | >64 |
| Providencia spp. | 80 | 8 | >64 | >64 |
| Proteus mirabilis | 32 | 8 | >64 | >64 |
| Serratia marcescens | 51 | 8 | >64 | >64 |
| CPE only (all) | 406 | 4 | >128 | >128 |
| Escherichia coli | 74 | 8 | >128 | >128 |
| Klebsiella pneumoniae | 236 | 4 | >128 | >128 |
| Enterobacter spp. | 48 | 8 | >128 | >128 |
| Citrobacter freundii | 48 | 4 | >128 | >128 |
| A. baumannii | 100 | 16 | >64 | >64 |
| CPA only | 17 | 16 | >256 | >256 |
| Geographic origin | ||||
| Europe | 799 | 8 | >64 | >64 |
| Asia | 240 | 8 | >256 | >256 |
| Africa | 107 | 8 | >256 | >256 |
| South America | 86 | 4 | >256 | >256 |
APR, apramycin; AMK, amikacin; GEN, gentamicin; CPE, carbapenemase-producing Enterobacteriaceae; CPA, carbapenemase-producing A. baumannii.