Table 4.
Longitudinal T0-Tx sub-analysis of separate DMFS[+] and DMFS[-] groups.
| DMFS+ | PERMANOVA Time: All Probes* | PERMANOVA Time: Caries Probes** |
|---|---|---|
| Subset-A [T0-T6] | 0.0001 | 0.0001 |
| Subset-A [T0-T18] | 0.0001 | 0.0006 |
| Subset-B [T0-T6] | 0.0056 | 0.0084 |
| Subset-B [T0-T18] | 0.0015 | 0.0030 |
| Subset-C [T0-T6] | 0.0091 | 0.0030 |
| Subset-C [T0-T18] | 0.0077 | 0.0052 |
| Subset-D [T0-T6] | 0.0001 | 0.0001 |
| Subset-D [T0-T18] |
0.0002 |
0.0002 |
| DMFS- |
PERMANOVA Time: All Probes* |
PERMANOVA Time: Caries Probes** |
| Subset-A [T0-T6] | 0.0001 | 0.0001 |
| Subset-A [T0-T18] | 0.0404 | 0.0842 |
| Subset-B [T0-T6] | 0.0001 | 0.0001 |
| Subset-B [T0-T18] | 0.1120 | 0.1397 |
| Subset-C [T0-T6] | 0.0001 | 0.0001 |
| Subset-C [T0-T18] | 0.2105 | 0.2592 |
| Subset-D [T0-T6] | 0.0001 | 0.0001 |
| Subset-D [T0-T18] | 0.0295 | 0.0177 |
Longitudinal PERMANOVA analyses were performed on square root transformed relative abundance data. T0 to Tx corresponds to baseline to 6-months post-RT sampling (T0-T6), or baseline to 18-months post-RT sampling (T0-T18). Monte-Carlo corrected p-values for the fixed variable ‘Time’ are shown with alpha significance level of 0.01.
T0: baseline sampling; T6: sampling at 6 months post-RT; T18: sampling at 18 months post-RT.
Set-1 subsets of patients with DMFS information were: Subset-A: all patients; Subset-B: all patients who did not receive induction chemotherapy; Subset-C: all patients who did not receive antibiotics; Subset-D: all patients who received concurrent chemotherapy.
*Species probes (n = 638) and genus probes (n = 129) (i.e., total of 767 probes)
**Probes for caries-associated species (n = 45).