BACTERIA |
Listeria monocytogenes |
Tregs cause increased pathogen burden (67) |
Detrimental |
Salmonella enterica |
Foxp3+ cell ablation accelerates bacterial clearance (68) |
Detrimental |
Aggregatibacter actinomycetemcomitans |
Tregs attenuate experimental periodontitis progression (69) |
Protective |
Yersinia Enterocolitica |
Tregs reduce pathogenic burden and attenuate inflammation (70) |
Protective |
VIRUSES |
HIV |
Early interference with the Treg's suppressive function worsened infection and inflammation (71, 72) |
Protective |
|
Tregs are preserved in elite controllers in humans (73) |
Protective |
|
Tregs suppress anti-viral CD8 responses (74) |
Detrimental |
|
Foxp3+ cell ablation accelerates mortality and increases viral load (197) |
Protective |
Herpes simplex virus 2 |
Foxp3+ cell ablation increases mortality (75) |
Protective |
West Nile virus |
|
|
PARASITES |
Toxoplasma gondii |
Loss of Foxp3+ Treg cells results in fatal pathology (76) |
Protective |
Toxoplasma gondii |
Loss of Foxp3+ Treg cells results in pathology (77) |
Protective |
Toxoplasma gondii |
Loss of Foxp3+ Treg cells results in pathology (78) |
Protective |
Heligmosomoides polygyrus |
No changes in pathogen burden with Treg ablation (79) |
No effect |
Leishmania major |
Tregs promote increased pathogen burden (80). |
Detrimental |
Schistosoma mansoni |
CD4+CD25+ depletion increases inflammation (81) |
Protective |
FUNGUS |
Candida albicans |
CD4+CD25+Tregs regulate immunopathology in Th1 mediated gastrointestinal/disseminated Candidiasis (82) |
Protective |
|
CD4+CD25+Foxp3+Tregs promote Th17 antifungal immunity and dampen immunopathology (41, 83) |
Protective |
|
Tregs regulate immunopathology (84) |
|
|
Tregs suppress pulmonary hyperinflammation (85) |
|
Aspergillus fumigatus |
|
Protective |
Pneumocystis carinii |
|
Protective |
MYCOBACTERIA |
Mycobacterium tuberculosis |
Selective depletion of Tregs reduces pathogen burden (86). |
Detrimental |
|
Foxp3+ cells induce resistance to TB lesions (87) |
Protective |