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. 2019 Mar 15;11:51. doi: 10.1186/s13148-019-0642-0

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© The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — LoD of SDC2 methylation test using data derived from Table 2. The LoD of the test using simulated stool DNA samples was determined by Probit analysis. The y-axis plots the probability of methylated SDC2 detection while the x-axis plots spiked HCT116 genomic DNA in a total of 2.0 μg of SDC2 methylation-negative stool genomic DNA. The estimated LoD (34.5 pg) is indicated by an arrow