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NST-1s suppresses necrotic cell death by decreasing the expression of receptor-interacting serine/threonine-protein kinase (RIPK)1, RIPK3, and mixed lineage kinase domain-like (pMLKL). Synovial tissue from CIA-induced control and NST-1s treated mice were subjected to immunohistochemical staining RIPK1, RIPK3, and pMLKL. The cells showing positively for RIPK1, RIPK3, and pMLKL were visually presented at a higher magnification. *p < 0.05; **p < 0.01; ***p < 0.001
