Table 10.

Summary of FKS Alterations in Echinocandin-Resistant Candida spp. Strains: SENTRY Program, 2006–2016

						1,3-β-D-Glucan Synthase Alterations
			MIC, mg/L			FKS1		FKS2
Year	Species	State/Country	ANF	CSF	MCF	HS1	HS2	HS1	HS2
2006–2009	C. albicans	Germany	0.12	1	0.06	F641I	WT	NT	NT
	C. glabrata	Germany	1	1	0.25	WT	WT	S663P	WT
	C. glabrata	Indiana USA	1	1	0.5	R631S S629P	WT	WT	WT
	C. glabrata	Indiana USA	1	1	NT	WT	WT	F659S	WT
	C. glabrata	Massachusetts USA	0.5	1	0.12	L630I	WT	WT	WT
	C. glabrata	Ohio USA	2	16	2	S629P	WT	WT	WT
	C. glabrata	Virginia USA	1	2	NT	WT	WT	F659V	WT
	C. glabrata	Washington USA	1	1	0.25	WT	WT	S663F	WT
	C. glabrata	Washington USA	2	4	2	S629P	WT	WT	WT
	C. tropicalis	Texas USA	1	0.5	0.5	S645P	WT	NT	NT
2010–2011	C. albicans	Scotland	0.5	2	1	S629P	WT	NT	NT
	C. albicans	Sweden	0.5	1	1	S654P	WT	NT	NT
	C. albicans	United Kingdom	0.5	0.5	0.5	F641S	WT	NT	NT
	C. glabrata	Australia	1	1	0.5	WT	WT	S663P	WT
	C. glabrata	Australia	0.5	0.25	0.12	F625S	WT	WT	WT
	C. glabrata	Canada	1	1	0.25	WT	WT	S659Y	WT
	C. glabrata	Germany	1	0.5	0.5	WT	WT	L662W	WT
	C. glabrata	Germany	1	0.5	0.5	WT	WT	L644W	WT
	C. glabrata	Greece	2	1	1	WT	WT	S663P	WT
	C. glabrata	Indiana USA	1	4	0.06	WT	WT	F659V	WT
	C. glabrata	Indiana USA	1	4	0.06	WT	WT	F641V	WT
	C. glabrata	Indiana USA	1	0.5	0.5	WT	WT	S663Y	WT
	C. glabrata	Louisiana USA	4	16	2	S629P	WT	WT	WT
	C. glabrata	Michigan USA	0.25	0.5	0.03	WT	WT	D648E	WT
	C. glabrata	Texas USA	0.5	0.25	0.03	F625Y	WT	WT	WT
	C. glabrata	Texas USA	0.5	0.25	0.03	WT	WT	F641Y	WT
2012–2013	C. dubliniensis	Belgium	2	2	1	S645P	WT	NT	NT
	C. glabrata	Canada	2	1	1	WT	WT	F659_del	WT
	C. glabrata	Canada	1	0.5	0.5	WT	WT	F659_del	WT
	C. glabrata	France	2	1	0.5	WT	WT	S663P	WT
	C. glabrata	Germany	0.5	0.5	0.06	WT	WT	D666E K753Q	WT
	C. glabrata	Kentucky USA	2	2	0.5	D632V	WT	WT	WT
	C. glabrata	New York USA	2	4	2	WT	WT	S663P	WT
	C. glabrata	New York USA	4	16	4	WT	WT	S663F	WT
	C. glabrata	New York USA	2	0.5	1	WT	WT	S663P	WT
	C. glabrata	Washington USA	2	2	1	WT	WT	S663F	WT
	C. kefyr	New York USA	2	0.5	1	WT	R1344S	NT	NT
	C. tropicalis	California USA	2	2	1	F641S	WT	NT	NT
	C. tropicalis	Indiana USA	1	0.5	0.5	F641L	WT	NT	NT
2014–2016	C. albicans	Indiana USA	0.5	1	1	S645P	WT	NT	NT
	C. albicans	Ireland	0.12	1	1	S645P	WT	NT	NT
	C. albicans	New York USA	0.25	1	1	S645P	WT	NT	NT
	C. albicans	Wisconsin USA	0.25	1	1	S645P	WT	NT	NT
	C. glabrata	California USA	2	8	2	S629P	WT	WT	WT
	C. glabrata	California USA	0.25	0.5	0.25	WT	WT	F659S	WT
	C. glabrata	California USA	1	1	0.25	F625S	WT	WT	WT
	C. glabrata	Canada	4	>8	4	S629P	WT	S663P	WT
	C. glabrata	Canada	4	>8	4	S629P	WT	S663P	WT
	C. glabrata	Colorado USA	1	1	0.25	WT	WT	F659S	WT
	C. glabrata	Georgia USA	2	2	0.5	F625S	WT	WT	WT
	C. glabrata	Indiana USA	2	2	0.5	F625S	WT	F659Y	WT
	C. glabrata	Iowa USA	4	4	1	WT	WT	S663P	WT
	C. glabrata	Israel	2	2	2	WT	WT	F659S	WT
	C. glabrata	Michigan USA	0.25	0.5	0.06	WT	WT	L662W	WT
	C. glabrata	New Jersey USA	1	1	1	WT	WT	S663P	WT
	C. glabrata	New York USA	4	>8	4	WT	WT	F659_del	WT
	C. glabrata	New York USA	0.25	0.5	0.03	WT	WT	P667T	WT
	C. glabrata	New York USA	0.5	0.25	0.25	WT	WT	S663P	WT
	C. glabrata	New York USA	2	2	2	WT	WT	S663P	WT
	C. glabrata	New York USA	2	1	1	WT	WT	S663P	WT
	C. glabrata	Utah USA	2	1	2	WT	WT	S663P	WT
	C. glabrata	Virginia USA	0.5	0.06	0.12	WT	WT	F658_del	WT
	C. glabrata	Washington USA	2	8	2	WT	WT	S663P	WT
	C. glabrata	Washington USA	2	4	1	WT	WT	S663P	WT
	C. tropicalis	Brazil	1	2	1	F650S	WT	NT	NT
	C. tropicalis	Colorado USA	1	>8	2	S654P	WT	NT	NT
	C. tropicalis	New Jersey USA	0.5	4	1	S645P	WT	NT	NT
	C. tropicalis	New York USA	0.5	4	1	S654P	WT	NT	NT
	C. tropicalis	New York USA	2	4	2	S654P	WT	NT	NT
	C. tropicalis	New York USA	2	4	2	S654P	WT	NT	NT

Abbreviations: ANF, andulafungin; CSF, caspofungin; HS, hot spot; MCF, micafungin; NT, not tested; WT, wild-type.