Table 11.
Activity of 4 Antifungal Agents Tested Against 15 Uncommonly Isolated Species of Candida (≥5 Isolates Each): SENTRY Program, 2006–2016
| MIC, mg/L | |||||
|---|---|---|---|---|---|
| Species | No. Tested | Antifungal Agent | Range | 50% | 90% |
| C. auris | 6 | Fluconazole | 64–>64 | >64 | |
| Anidulafungin | 0.25–1 | 0.5 | |||
| Caspofungin | 0.12–0.5 | 0.25 | |||
| Micafungin | 0.12–0.5 | 0.25 | |||
| C. bracarensis | 5 | Fluconazole | 1–4 | 2 | |
| Anidulafungin | 0.03–0.12 | 0.06 | |||
| Caspofungin | 0.03–0.06 | 0.03 | |||
| Micafungin | 0.015–0.03 | 0.015 | |||
| C. dubliniensis | 264 | Fluconazole | ≤0.5–32 | ≤0.5 | ≤0.5 |
| Anidulafungin | ≤0.008–2 | 0.06 | 0.12 | ||
| Caspofungin | ≤0.008–2 | 0.03 | 0.12 | ||
| Micafungin | ≤0.008–1 | 0.03 | 0.06 | ||
| C. fabianii | 14 | Fluconazole | ≤0.5–4 | 1 | 4 |
| Anidulafungin | 0.015–0.12 | 0.015 | 0.12 | ||
| Caspofungin | 0.015–0.25 | 0.03 | 0.06 | ||
| Micafungin | 0.015–0.06 | 0.03 | 0.06 | ||
| C. fermentati | 29 | Fluconazole | 0.25–>128 | 2 | 32 |
| Anidulafungin | 0.5–2 | 1 | 2 | ||
| Caspofungin | 0.06–1 | 0.25 | 0.5 | ||
| Micafungin | 0.12–1 | 0.25 | 1 | ||
| C. guilliermondii | 91 | Fluconazole | ≤0.5–>64 | 4 | 64 |
| Anidulafungin | 0.06–8 | 2 | 4 | ||
| Caspofungin | 0.06–>16 | 0.5 | 1 | ||
| Micafungin | 0.03–8 | 1 | 1 | ||
| C. haemulonii | 10 | Fluconazole | 0.5–32 | 2 | 4 |
| Anidulafungin | 0.06–1 | 0.12 | 0.5 | ||
| Caspofungin | 0.03–0.12 | 0.06 | 0.12 | ||
| Micafungin | 0.03–0.25 | 0.12 | 0.25 | ||
| C. inconspicua | 12 | Fluconazole | 4–>128 | 16 | >64 |
| Anidulafungin | ≤0.008–0.03 | 0.015 | 0.03 | ||
| Caspofungin | 0.015–0.25 | 0.03 | 0.25 | ||
| Micafungin | ≤0.008–0.12 | 0.03 | 0.06 | ||
| C. kefyr | 94 | Fluconazole | ≤0.5–1 | ≤0.5 | ≤0.5 |
| Anidulafungin | 0.03–2 | 0.06 | 0.12 | ||
| Caspofungin | ≤0.008–0.5 | 0.015 | 0.12 | ||
| Micafungin | 0.015–1 | 0.06 | 0.12 | ||
| C. lipolytica | 10 | Fluconazole | 0.25–32 | 2 | 32 |
| Anidulafungin | 0.25–0.5 | 0.25 | 0.5 | ||
| Caspofungin | 0.12–0.25 | 0.12 | 0.25 | ||
| Micafungin | 0.06–1 | 0.5 | 1 | ||
| C. lusitaniae | 277 | Fluconazole | ≤0.5–64 | ≤0.5 | 1 |
| Anidulafungin | 0.015–2 | 0.25 | 0.5 | ||
| Caspofungin | 0.015–2 | 0.25 | 0.5 | ||
| Micafungin | 0.015–2 | 0.12 | 0.25 | ||
| C. metapsilosis | 33 | Fluconazole | 0.12–16 | 1 | 8 |
| Anidulafungin | 0.015–2 | 0.25 | 0.5 | ||
| Caspofungin | 0.03–0.5 | 0.12 | 0.25 | ||
| Micafungin | 0.015–1 | 0.25 | 0.5 | ||
| C. orthopsilosis | 82 | Fluconazole | ≤0.12–>128 | 1 | 2 |
| Anidulafungin | 0.12–2 | 0.5 | 2 | ||
| Caspofungin | 0.03–0.5 | 0.12 | 0.25 | ||
| Micafungin | 0.06–1 | 0.5 | 1 | ||
| C. pararugosa | 7 | Fluconazole | 1–>128 | 4 | |
| Anidulafungin | 0.06–0.25 | 0.12 | |||
| Caspofungin | 0.06–0.25 | 0.12 | |||
| Micafungin | 0.015–0.25 | 0.12 | |||
| C. pelliculosa | 22 | Fluconazole | 0.5–8 | 2 | 4 |
| Anidulafungin | ≤0.008–0.12 | 0.015 | 0.03 | ||
| Caspofungin | ≤0.008–0.5 | 0.03 | 0.25 | ||
| Micafungin | ≤0.008–0.06 | 0.03 | 0.06 | ||