Table 7.
Trends in Echinocandin Resistance: SENTRY Program, 2006–2016
| Species | Year | No. Tested | Antifungal Agent | % Resistant (No.) |
|---|---|---|---|---|
| C. albicans | 2006–2008 | 1356 | Anidulafungin | 0.0 (0) |
| Caspofungin | 0.1 (1) | |||
| Micafungin | 0.0 (0) | |||
| 2009–2011 | 1849 | Anidulafungin | 0.0 (0) | |
| Caspofungin | 0.2 (3) | |||
| Micafungin | 0.1 (2) | |||
| 2012–2014 | 2283 | Anidulafungin | 0.0 (0) | |
| Caspofungin | <0.1 (1) | |||
| Micafungin | <0.1 (1) | |||
| 2015–2016 | 1691 | Anidulafungin | 0.0 (0) | |
| Caspofungin | 0.2 (3) | |||
| Micafungin | 0.2 (3) | |||
| 2006–2016 | 7179 | Anidulafungin | 0.0 (0) | |
| Caspofungin | 0.1 (8) | |||
| Micafungin | 0.1 (6) | |||
| C. glabrata | 2006–2008 | 420 | Anidulafungin | 2.6 (11) |
| Caspofungin | 6.9 (29) | |||
| Micafungin | 2.8 (6) | |||
| 2009–2011 | 773 | Anidulafungin | 1.8 (14) | |
| Caspofungin | 4.5 (35) | |||
| Micafungin | 1.0 (8) | |||
| 2012–2014 | 951 | Anidulafungin | 2.8 (27) | |
| Caspofungin | 2.9 (28) | |||
| Micafungin | 2.4 (23) | |||
| 2015–2016 | 716 | Anidulafungin | 1.5 (11) | |
| Caspofungin | 1.3 (9) | |||
| Micafungin | 1.3 (9) | |||
| 2006–2016 | 2860 | Anidulafungin | 2.2 (63) | |
| Caspofungin | 3.5 (101) | |||
| Micafungin | 1.7 (46) | |||
| C. parapsilosis | 2006–2008 | 446 | Anidulafungin | 0.0 (0) |
| Caspofungin | 0.0 (0) | |||
| Micafungin | 0.0 (0) | |||
| 2009–2011 | 717 | Anidulafungin | 0.4 (3) | |
| Caspofungin | 0.0 (0) | |||
| Micafungin | 0.0 (0) | |||
| 2012–2014 | 744 | Anidulafungin | 0.0 (0) | |
| Caspofungin | 0.0 (0) | |||
| Micafungin | 0.0 (0) | |||
| 2015–2016 | 526 | Anidulafungin | 0.0 (0) | |
| Caspofungin | 0.0 (0) | |||
| Micafungin | 0.0 (0) | |||
| 2006–2016 | 2433 | Anidulafungin | 0.1 (3) | |
| Caspofungin | 0.0 (0) | |||
| Micafungin | 0.0 (0) | |||
| C. tropicalis | 2006–2008 | 282 | Anidulafungin | 0.0 (0) |
| Caspofungin | 1.1 (3) | |||
| Micafungin | 0.0 (0) | |||
| 2009–2011 | 407 | Anidulafungin | 0.2 (1) | |
| Caspofungin | 0.0 (0) | |||
| Micafungin | 0.0 (0) | |||
| 2012–2014 | 426 | Anidulafungin | 0.5 (2) | |
| Caspofungin | 0.2 (1) | |||
| Micafungin | 0.2 (1) | |||
| 2015–2016 | 303 | Anidulafungin | 1.3 (4) | |
| Caspofungin | 2.0 (6) | |||
| Micafungin | 2.0 (6) | |||
| 2006–2016 | 1418 | Anidulafungin | 0.5 (7) | |
| Caspofungin | 0.7 (10) | |||
| Micafungin | 0.6 (7) | |||
| C. krusei | 2006–2008 | 55 | Anidulafungin | 3.6 (2) |
| Caspofungin | 7.3 (4) | |||
| Micafungin | 0.0 (0) | |||
| 2009–2011 | 107 | Anidulafungin | 0.0 (0) | |
| Caspofungin | 1.9 (2) | |||
| Micafungin | 0.0 (0) | |||
| 2012–2014 | 158 | Anidulafungin | 0.6 (1) | |
| Caspofungin | 0.6 (1) | |||
| Micafungin | 0.0 (0) | |||
| 2015–2016 | 101 | Anidulafungin | 0.0 (0) | |
| Caspofungin | 0.0 (0) | |||
| Micafungin | 0.0 (0) | |||
| 2006–2016 | 421 | Anidulafungin | 0.7 (3) | |
| Caspofungin | 1.7 (7) | |||
| Micafungin | 0.0 (0) |
Echinocandin-resistant breakpoints are ≥1 mg/L for all 3 agents and C. albicans, C. tropicalis, and C. krusei; ≥8 mg/L for all 3 agents and C. parapsilosis; ≥0.5 mg/L for anidulafungin and caspofungin; and ≥0.25 mg/L for micafungin and C. glabrata.