Table 5.
Activity of Distinct Antimicrobial Agents Tested Against 7772 Acinetobacter calcoacetius–A. baumannii Complexa Isolates Categorized as Extensively Drug-Resistant (SENTRY Program, 1997–2016)
| CLSIb | EUCASTb | |||||
|---|---|---|---|---|---|---|
| Antimicrobial Agent | MIC50, mg/L | MIC90, mg/L | %S | %R | %S | %R |
| Amikacin | >32 | >32 | 16.0 | 78.2 | 12.4 | 84.0 |
| Ampicillin-sulbactam | >16 | >16 | 9.2 | 76.9 | c | c |
| Cefepime | >16 | >16 | 3.6 | 85.9 | c | c |
| Ceftazidime | >16 | >16 | 2.4 | 94.1 | c | c |
| Colistin (6520)d | ≤0.5 | 2 | 95.1 | 4.9 | 95.1 | 4.9 |
| Gentamicin | >8 | >8 | 8.0 | 85.8 | 8.0 | 92.0 |
| Imipenem | >8 | >8 | 12.8 | 82.6 | 12.8 | 78.2 |
| Levofloxacin | >4 | >4 | 1.3 | 90.2 | 0.1 | 99.5 |
| Meropenem | >8 | >8 | 8.1 | 86.3 | 8.1 | 79.6 |
| Minocycline (5961)d | 2 | >8 | 72.7 | 13.6 | c | c |
| Piperacillin-tazobactam | >64 | >64 | 0.9 | 95.4 | c | c |
| Tigecycline (6981)d | 1 | 4 | c | c | c | c |
| Tobramycin | >8 | >8 | 27.0 | 68.5 | 27.0 | 73.0 |
| Trimethoprim-sulfamethoxazole | >1 | >1 | 14.7 | 85.3 | 14.7 | e |
Abbreviations: CLSI, Clinical and Laboratory Standards Institute; EUCAST, European Committee on Antimicrobial Susceptibility Testing; MIC, minimum inhibitory concentration; R, resistant; S, susceptible.
aOrganisms include A. baumannii (6), A. calcoacetius–A. baumannii complex (7756), A. nosocomialis (4), A. pittii (6).
dLess than 90% of isolates tested against these antimicrobials; number of isolates tested is cited in parentheses.
eDilution range did not extend high enough to determine between intermediate and R, so only the S percentage is displayed.