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. 2018 Aug 23;35(6):981–986. doi: 10.1093/bioinformatics/bty713

Fig. 3.

Fig. 3.

Comparison of quantile normalization on 52 GB β matrix from Marmal-aid dataset (n = 14 586) using limma::normalizeQuantiles function and bigmelon::qn.gdsn, computation was performed on a single core computer with 500GB of memory