Comparison 1.

Hypothermic machine perfusion versus static cold storage

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Delayed graft function	14	2138	Risk Ratio (M‐H, Random, 95% CI)	0.77 [0.67, 0.90]
2 Delayed graft function: type of donor	14	2138	Risk Ratio (M‐H, Random, 95% CI)	0.78 [0.68, 0.89]
2.1 DCD	7	772	Risk Ratio (M‐H, Random, 95% CI)	0.75 [0.64, 0.87]
2.2 DBD	4	971	Risk Ratio (M‐H, Random, 95% CI)	0.78 [0.65, 0.93]
2.3 Type of donor not specified	4	395	Risk Ratio (M‐H, Random, 95% CI)	0.81 [0.46, 1.44]
3 Delayed graft function: era of study	14	2138	Risk Ratio (M‐H, Random, 95% CI)	0.77 [0.67, 0.90]
3.1 Modern era	5	1355	Risk Ratio (M‐H, Random, 95% CI)	0.77 [0.66, 0.91]
3.2 Pre‐2008	9	783	Risk Ratio (M‐H, Random, 95% CI)	0.78 [0.61, 0.99]
4 Delayed graft function: preservation times	14	2138	Risk Ratio (M‐H, Random, 95% CI)	0.77 [0.67, 0.90]
4.1 Short mean cold ischaemic time (< 24 hours)	6	1288	Risk Ratio (M‐H, Random, 95% CI)	0.86 [0.70, 1.04]
4.2 Long mean cold ischaemic time (≥ 24 hours)	6	725	Risk Ratio (M‐H, Random, 95% CI)	0.69 [0.57, 0.83]
4.3 Cold ischaemic time not reported	2	125	Risk Ratio (M‐H, Random, 95% CI)	0.82 [0.31, 2.18]
5 Primary non‐function	7	1387	Risk Ratio (M‐H, Random, 95% CI)	0.88 [0.58, 1.33]
6 Duration of DGF	4	220	Mean Difference (IV, Random, 95% CI)	‐1.23 [‐5.87, 3.40]
7 One year patient survival	3	920	Risk Ratio (M‐H, Random, 95% CI)	0.99 [0.95, 1.03]
8 Treated acute rejection in the first year	2	248	Risk Ratio (M‐H, Random, 95% CI)	0.66 [0.37, 1.17]