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. 2019 Mar 15;2019(3):CD011671. doi: 10.1002/14651858.CD011671.pub2
Methods
  • Study design: unclear whether this study was randomised or quasi‐randomised

  • Duration of study: Total study duration was 35 months

  • Duration of follow‐up: not reported

Participants
  • Country: South Africa

  • Setting: not reported

  • Donor characteristics

    • Mean age ± SD (years): not reported

    • Number of DCD: 0

    • Sex (M/F); not reported

    • Inclusion criteria: DBD victims of trauma who were haemodynamically stable and who continued to pass urine

    • Exclusion criteria: one of the kidneys was transplanted into a recipient who had already received a kidney transplant

  • Recipient characteristics

    • Inclusion criteria: not reported

    • Exclusion criteria: not reported. one of the kidneys was transplanted into a recipient who had already received a kidney transplant

    • Sex (M/F): not reported

    • Mean age, range (years): MP group (34, 11 to 53); SCS group (53, 1 to 56)

Interventions Machine perfusion
  • Waters Inc. t000 pulsatile perfusion machine (Rochester, Minnesota, USA) using cryoprecipitated plasma


Static cold storage
  • UW solution


Mean CIT
  • Did not differ significantly between the groups; 18 (7‐34) in the SCS group and 19 (7‐33) in the MP group

Outcomes
  • DGF

  • Functional DGF based on creatinine

Notes
  • 36 kidneys from 18 donors. All were DBD donors.

  • One kidney from each pair assigned to MP and the other to SCS

  • The manuscript presents two studies, a paired study of 18 donors, and a retrospective analysis of previous cases. Only the data from the paired population has been collected.

  • This study has a small sample size, and took place over a long duration.

  • "Only donors of excellent quality were used for the study".

  • Funding source: not reported

Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk It does not state how or at what stage the decision was made as to which kidney would receive MP and which would receive SCS. Moreover it is unclear whether the study was randomised or quasi‐randomised.
Allocation concealment (selection bias) Unclear risk Insufficient information to permit judgement
Blinding of participants and personnel (performance bias) All outcomes Low risk No blinding, but comparable CIT between the groups, and the study does describe randomisation of kidneys in terms of allocation to recipients
Blinding of outcome assessment (detection bias) All outcomes Low risk No blinding, but outcome measurements are unlikely to be affected by the lack of blinding
Incomplete outcome data (attrition bias) All outcomes Low risk Data is available for all included participants
Selective reporting (reporting bias) Low risk Suitable outcome measures with results reported for each
Other bias Unclear risk Relatively short manuscript lacking details of methods of randomisation