Fig. 3. Synthetic utility of iodine-catalyzed β C–H amination of imidates. Conditions: 0.4 mmol imidate, I2 (5 mol%), PhI(OAc)2 (1.2 equiv.), DMF (0.2 M), 50 °C. 1H NMR yield of oxazoline determined vs. standard. Hydrolysis with HCl (2 M) affords amino alcohol (isolated yield, in parenthesis). aIsolated yield of oxazoline. bStoichiometric NaI (ref. 12). Ac* refers to trichloroacetamide. Functional group robustness: C–H amination yield, % additive remaining.
