Fig. 7. (a) Body weight change of the mice in different groups. (b) Changes of the tumor volume in different groups. *, P < 0.05; ***, P < 0.001; ****, P < 0.0001 (significant differences compared to the laser only group). (c) Tumors excised from the mice in different groups after the treatment for 12 days. (d) H&E and (e) Ki-67 staining of tumor tissues treated with laser only, SC NPs only, and SC NPs + laser groups.