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. Author manuscript; available in PMC: 2019 Mar 15.
Published in final edited form as: Chem Eng J. 2018 May 15;340:155–172. doi: 10.1016/j.cej.2018.01.060

Fig. 2.

Fig. 2

Scheme of the possible mechanism of SDT assisted by microbubbles (MBs) loaded with organic sonosensitizer molecules. The MBs are injected in the blood stream and can accumulate in the tumor tissue. Upon the ultrasound stimulation, the MBs produce cavitation and thus sono-luminescence emission and pyrolysis reactions. Thanks to the organic sonosensitizer molecules included in the MBs, the formation of highly cytotoxic reactive oxygen species (ROS) and singlet oxygen (1O2) take place, leading to cancer cell death. Reprinted with permission, Copyright 2016, John Wiley & Sons Inc. [89].