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. Author manuscript; available in PMC: 2019 Mar 15.
Published in final edited form as: J R Stat Soc Ser C Appl Stat. 2018 Nov 22;68(2):309–329. doi: 10.1111/rssc.12323

Fig. 4.

Fig. 4

A single illustrative trial using TITE-PIPE simulated over Scenario A, with θ = 0.20. At least two patients were required to have completed treatment on a dose combination before a new combination could be considered for future patients. Combinations marked m(n) + r(s) indicate that of m patients with complete follow-up, n have experienced DLT, and of r that have been assigned to the same combination, s patient-time units are unobserved and therefore count as DLTs at time t. MTC denoted by solid black contour. Safety threshold denoted by dashed red contour. True MTC denoted in MTDC recommendations figure by blue dot-dashed line.