Extended Data Figure 1. Flow cytometry reanalysis of isolated cell nuclei from multiple sclerosis patients.

a, b, c, Reanalysis of flow cytometry isolated mature oligodendrocytes, oligodendrocyte progenitor cells and non-oligodendrocyte lineage cells show 94.8 ± 2.1%, 82.2 ± 10.2% and 97.6± 2.1% purity respectively (n = 29, n = 24 and n = 28) and the respective contamination of oligodendrocyte progenitor cells (upper left quadrant), non-oligodendrocyte linage cells (lower left quadrant) and mature oligodendrocyte (upper right quadrant) in the isolated population. Value inside the quadrants represent average percentage from all isolated normal appearing white matter of multiple sclerosis patients (mean ± s.d.). The small fraction of contamination of other than the isolated population acquired during flow cytometry isolation was accounted by correcting the ¹⁴C values to accurately reflect the isolated cell population. See also Method section and Supplementary Table 1.