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. Author manuscript; available in PMC: 2019 Jul 14.
Published in final edited form as: Nat Nanotechnol. 2019 Jan 14;14(2):184–190. doi: 10.1038/s41565-018-0336-3

Fig. 3. Spatial tolerance is lower in low affinity Abs.

Fig. 3

A comparison of human anti-NIP IgG1 and IgG3 binding to NIP or NP. The x-axis is the separation distance between two antigens. See, Fig. 2 and Supplementary Fig. 6 for exact structure designs. The point at 0 represents a structure with one antigen. NIP data points are identical to that of Fig. 2, and their binding affinities correspond to the right, blue, y-axis. NP binding affinity (KD) is plotted on the red, left, y-axis. (n=3; central values = average value; error bars = standard error of mean. For samples without error bars n =1)