. Author manuscript; available in PMC: 2019 Jul 2.

Published in final edited form as: Nature. 2019 Jan 2;565(7738):230–233. doi: 10.1038/s41586-018-0818-3

Table 1. Characteristics of the 2016-2017 Yemeni cholera epidemic strain.

Species	Vibrio cholerae
Serogroup, serotype and biotype	O1, Ogawa, El Tor
Genomic wave	3
Genetic markers	ctxB7, tcpA^CIRS101, rtxA°, VSP-II^Δ*
AMR profile	POL^S (1-2 mg/L), COL^S (2-8 mg/L), O129^R‡, NAL^R (64 - ≥ 256 mg/L), CIP^DS (0.25-0.5 mg/L), FT^R
Horizontally acquired AMR element, acquired AMR gene (AMR phenotype)	ICEVchInd5/ICEVchBan5^Δ*, dfrA1* (O129^R)
Mutated chromosomal genes (AMR phenotype)	gyrA_S83I and parC_S85L (NAL^R, CIP^DS) nfsA_R169C and nfsB_Q5Stop (FT^R)

AMR, antimicrobial resistance; POL, polymyxin B; COL, polymyxin E; NAL, nalidixic acid; CIP, ciprofloxacin; FT, nitrofurantoin; MIC range values are indicated in parentheses; R, S, and DS in uppercase indicate resistant, susceptible, and decreased susceptibility, respectively

^Δ*

Deletion encompassing VC_0495-VC_0512 according to GenBank accession no. AE003852

^Δ**

Deletion encompassing ICEVCHIND5_0011- ICEVCHIND5_0021 according to GenBank accession no. GQ463142

^‡

cross-resistance to the vibriostatic agent O/129 and trimethoprim.