. Author manuscript; available in PMC: 2019 Jul 2.

Published in final edited form as: Nature. 2019 Jan 2;565(7738):230–233. doi: 10.1038/s41586-018-0818-3

Extended Data Table 2. Gene alteration frequencies in isolates susceptible or resistant to certain antibiotics.

FT, nitrofurantoin; POL, polymyxin B; *720 genomes with antimicrobial susceptibility testing data (this study and reference 2) or **106 genomes with antimicrobial susceptibility testing data (this study).

	Number (%) of isolates:
VCA_0637	FT^S	FT^R
Wild-type	258 (94.2)	0 (0)
Genetic alteration	16 (5.8)	446 (100)

Total	274	446	720*

	Number (%) of isolates:
VC_0715	FT^S	FT^R
Wild-type	264 (96.4)	5 (1.1)
Genetic alteration	10 (3.6)	441 (98.9)

Total	274	446	720*

	Number (%) of isolates:
VCA_0637 and VC_0715	FT^S	FT^R
Wild-type	258 (94.2)	0 (0)
Genetic alteration	16 (5.8)	446 (100)

Total	274	446	720*

	Number (%) of isolates:
VC_1320	POL^S	POL^A
Wild-type	2 (3.1)	40 (97.6)
D89N	63 (96.9)	1(2.4)

Total	65	41	106**