Table 2. Summaries of primary and secondary measures at each visit.
| All Patients | Adults Only | |||
|---|---|---|---|---|
| Milk Thistle | Placebo | Milk Thistle | Placebo | |
| NIMH Trichotillomania Severity Scale | ||||
| Baseline (n=17/17/14/15)1 | 9.6 (5.6) | 9.7 (4.5) | 9.0 (5.8) | 10.1 (4.7) |
| Week 2 (n=18/18/15/15) | 9.7 (5.3) | 7.9 (4.5) | 9.7 (5.6) | 8.0 (4.7) |
| Week 4 (n=18/18/15/15) | 8.2 (5.7) | 8.4 (5.3) | 9.1 (5.8) | 8.4 (5.5) |
| Week 6 (n=17/16/14/13) | 6.4 (5.5) | 7.7 (5.0) | 7.4 (5.4) | 8.4 (5.2) |
| P-value (BL to Week 6 change)2 | 0.054 | 0.088 | 0.230 | 0.110 |
| NIMH Trichotillomania Severity Scale –Question 1 – | ||||
| Baseline (n=19/17/15/15) | 2.7 (1.8) | 2.5 (1.4) | 2.5 (1.8) | 2.7 (1.4) |
| Week 2 (n=18/18/15/15) | 2.6 (1.6) | 2.1 (1.6) | 2.4 (1.6) | 2.3 (1.7) |
| Week 4 (n=18/18/15/15) | 2.2 (1.5) | 2.4 (1.6) | 2.3 (1.6) | 2.3 (1.6) |
| Week 6 (n=17/16/14/13) | 1.6 (1.4) | 1.9 (1.6) | 1.8 (1.4) | 2.2 (1.7) |
| P-value (BL to Week 6 change) | 0.039 | 0.144 | 0.131 | 0.145 |
| Massachusetts General Hospital Hair Pulling Scale –Total Score – | ||||
| Baseline (n=19/17/15/15) | 14.9 (5.7) | 16.5 (4.8) | 15.0 (6.0) | 16.3 (5.0) |
| Week 2 (n=18/18/15/15) | 15.3 (6.4) | 13.8 (5.5) | 16.1 (6.6) | 14.1 (5.7) |
| Week 4 (n=18/18/15/15) | 13.8 (7.6) | 13.9 (5.2) | 15.1 (7.1) | 14.0 (5.6) |
| Week 6 (n=17/16/14/13) | 11.5 (6.8) | 14.0 (5.3) | 12.5 (6.3) | 14.3 (5.4) |
| P-value (BL to Week 6 change) | 0.020 | 0.127 | 0.066 | 0.169 |
| CGI Severity - | ||||
| Baseline (n=17/17/14/15) | 4.2 (1.0) | 4.0 (0.6) | 4.1 (1.1) | 4.1 (0.6) |
| Week 2 (n=18/18/15/15) | 3.8 (1.2) | 3.6 (1.0) | 3.9 (1.1) | 3.7 (1.0) |
| Week 4 (n=18/18/15/15) | 3.6 (1.3) | 3.6 (1.0) | 3.8 (1.3) | 3.6 (1.1) |
| Week 6 (n=17/16/14/13) | 3.0 (1.4) | 3.6 (0.9) | 3.3 (1.3) | 3.8 (0.8) |
| P-value (BL to Week 6 change) | 0.004 | 0.173 | 0.006 | 0.175 |
| CGI Improvement – n (%) Much/Very Much Improved | ||||
| Week 2 (n=18/18/15/15) | 4 (22.2%) | 4(22.2%) | 1 (6.7%) | 3 (20.0%) |
| Week 4 (n=18/18/15/15) | 6 (33.3%) | 5(27.8%) | 4 (26.7%) | 5 (33.3%) |
| Week 6 (n=17/16/14/13) | 7 (41.2%) | 5(31.3%) | 5 (35.7%) | 4 (30.8%) |
| Sheehan Disability Scale - | ||||
| Baseline (n=18/17/15/15) | 9.7 (9.1) | 10.5 (5.4) | 8.7 (9.5) | 10.7 (5.4) |
| Week 2 (n=18/18/15/15) | 8.3 (8.3) | 8.1 (8.3) | 8.9 (9.0) | 8.4 (8.8) |
| Week 4 (n=18/18/15/15) | 6.8 (8.1) | 7.1 (7.6) | 7.6 (8.5) | 7.3 (8.3) |
| Week 6 (n=17/16/14/13) | 5.3 (7.8) | 6.0 (6.8) | 5.8 (8.4) | 6.4 (7.3) |
| P-value (BL to Week 6 change) | 0.027 | 0.004 | 0.056 | 0.008 |
| Hamilton Anxiety Scale - | ||||
| Baseline (n=17/17/14/15) | 5.9 (5.6) | 5.1 (4.5) | 6.1 (6.1) | 4.1 (3.9) |
| Week 2 (n=18/18/15/15) | 4.6 (4.3) | 4.7 (3.6) | 4.8 (4.7) | 4.7 (3.8) |
| Week 4 (n=18/18/15/15) | 4.5 (5.1) | 5.1 (3.4) | 4.8 (5.5) | 4.5 (3.2) |
| Week 6 (n=17/16/14/13) | 2.8 (3.5) | 3.3 (3.1) | 2.7 (3.7) | 3.1 (3.5) |
| P-value (BL to Week 6 change) | 0.125 | 0.100 | 0.183 | 0.342 |
| Hamilton Depression Scale - | ||||
| Baseline (n=17/17/14/15) | 6.6 (5.8) | 5.5 (4.4) | 5.6 (5.4) | 4.9 (4.3) |
| Week 2 (n=18/18/15/15) | 4.1 (3.6) | 4.5 (4.6) | 4.3 (3.9) | 4.1 (4.1) |
| Week 4 (n=18/18/15/15) | 4.8 (5.9) | 4.4 (3.6) | 4.9 (6.3) | 3.3 (2.7) |
| Week 6 (n=18/16/14/13) | 2.8 (3.2) | 2.6 (2.8) | 2.7 (3.6) | 2.1 (2.8) |
| P-value (BL to Week 6 change) | 0.054 | 0.012 | 0.230 | 0.047 |
All values are Mean (SD) unless otherwise noted
1
The number of participants with complete data is indicated for each group for each measure at each time point in the following notation: n= All patients: placebo condition/milk thistle condition/adults only: placebo condition/milk thistle condition.
2
p-values corresponds to the mean within-person change from baseline to week 6 within each study condition.