Table 6.

Mean CMAB008 plasma noncompartmental pharmacokinetic parameters following single doses in healthy volunteers

	Single-dose groups of CMAB008
	1 mg/kg (n=9)	3 mg/kg (n=9)	10 mg/kg (n=9)
k (hours)	0.0066±0.0020	0.0041±0.0008c	0.0033±0.0006a,b
AUC0–t (µg·h/mL)	2,375±616	9,037±2,761c	41,060±7,336b,d
AUC0–∞ (µg·h/mL)	2,434±692	9,183±2,758c	41,687±7,599b,d
AUCt–∞ % (%)	1.83±3.7	1.37±1.0	1.44±1.0
MRT (hours)	165±45	239±49c	287±39a,b
t½ (hours)	116±36	149±44c	214±35a,b
CL/F (mL·h/kg)	0.417±0.109	0.342±0.104	0.239±0.045a,b
Vss (mL/kg)	77±24	86±18	75±14
Cmax (µg/mL)	22.5±4.0	51.6±13.0c	218.9±47.6b,d
Tmax (hours)	3±1	2±0	2±0
Vz/F (mL/kg)	90±49	72±15	75±15

Notes: Data expressed as mean±SD.

^aP<0.05, 3 mg/kg vs 10 mg/kg;

^bP<0.01, 1 mg/kg vs 10 mg/kg;

^cP<0.01, 3 mg/kg vs 1 mg/kg;

^dP<0.013 mg/kg vs 10 mg/kg.

Abbreviation: MRT, mean residence time.