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. Author manuscript; available in PMC: 2019 Mar 15.
Published in final edited form as: Immunol Lett. 2016 Sep 14;179:85–94. doi: 10.1016/j.imlet.2016.09.006

Fig. 3.

Fig. 3

Obesity-associated AT inflammation is not diminished after immunization with OPN-derived peptides, The cardio-metabolic model (Ldlr−/− mice) was fed either a DDC or NC for 17 weeks (n = 11–15 per group) and immunized with three different OPN-based peptides, scrambled control. Adj-KLH and PBS, as indicated. Expression of macrophage markers Emr1 (F4/80) (A) and Itgax (B) by qRT-PCR as well as cytokines like Spp1 (C) and Adipoq (D) was assessed in GWAT. Ubiquitin was used as a housekeeping gene. Data is expressed as mean ± SEM and shown after normalization to the mean of control peptide 1. ***p ≤ 0.001, one-way ANOVA and unpaired Student’s t-test, as indicated.