Figure 3.

CD4⁺ T-cell herpes simplex virus type 1 (HSV-1) protein-level specificity patterns are similar between monozygotic (MZ) twins. A, Representative HSV-1 proteome-wide reactivity to 90 HSV-1 proteins or protein fragments for a MZ twin pair. Responses to each HSV-1 open reading frame, measured in counts per million (CPM), were designated as positive or negative by using a cutoff set with negative control antigens from unrelated microbes. Data are from twin pair 7 in panel B. B, Summarized peripheral blood mononuclear cell (PBMC) CD4⁺ T-cell reactivity to 77 HSV-1 proteins (fragment responses condensed) in 10 MZ twin pairs. Twin pair participants are listed on the y-axis. Responses are designated as positive (darker shading or colored) or negative per the cutoff described in Methods. MZ twins in adjacent rows have the same shading/color.