Table 1.
Active Food and Drug Administration–Approved Compounds Identified from the St. Jude Children’s Research Hospital Library
| Class, Compound | IC50, μM |
|---|---|
| Antibiotics | |
| Azithromycina | 0.02 |
| Azithromycin dihydratea | 0.02 |
| Clarithromycin | 0.03 |
| Valnemulin hydrochloride | 0.04 |
| Tilmicosin | 0.06 |
| Erythromycin ethylsuccinatea | 0.10 |
| (-)-Erythromycina | 0.12 |
| Roxithromycin | 0.20 |
| Dirithromycin | 0.39 |
| Retapamulin | 0.44 |
| Antifungals | |
| Itraconazole | 0.08 |
| Posaconazole | 0.24 |
| Butenafine hydrochloride | 0.42 |
| Ketoconazole | 1.37 |
| Terbinafine hydrochloridea | 3.00 |
| Liranaftate | 5.42 |
| Terbinafinea | 6.05 |
| Nucleosides | |
| Gemcitabinea | 0.34 |
| Gemcitabine hydrochloridea | 0.36 |
| Fludarabine phosphate | 0.58 |
| Clofarabine | 1.76 |
| Proteasome inhibitor | |
| Bortezomib | 0.60 |
| HDAC inhibitor | |
| Vorinostat | 1.26 |
| HMG-CoA reductase | |
| Pitavastatin | 3.52 |
Abbreviations: CoA, coenzyme A; HDAC, histone deacetylase; IC50, 50% inhibitory concentration.
aDifferent salts were included in the compound library.