Table 2.
Active Compounds From the Medicines for Malaria Venture (MMV) Pathogen Box
| Compound | Other Name | IC50, μM | Disease Seta | Source(s) |
|---|---|---|---|---|
| MMV688774 | Posaconazole | 0.86 | Reference | NA |
| MMV652003 | AN3520 | 1.10 | Kinetoplastids | [23, 25] |
| MMV688180 | DDD85646 | 1.44 | Kinetoplastids | [26–28] |
| MMV024406 | NA | 1.61 | Kinetoplastids | [26–28] |
| MMV676602 | Milciclib | 1.78 | Kinetoplastids | [29, 30] |
| MMV676604 | NA | 2.17 | Kinetoplastids | [30] |
| MMV688943 | Difenoconazole | >10 | Kinetoplastids | [30] |
| MMV688942 | Bitertanol | >10 | Kinetoplastids | [30] |
| MMV689244 | NA | >10 | Kinetoplastids | [30] |
| MMV689243 | NA | >10 | Kinetoplastids | [30] |
| MMV006741 | NA | >10 | Malaria | [30] |
| MMV1019989 | NA | >10 | Malaria | [30] |
| MMV1037162 | NA | >10 | Malaria | [30] |
Abbreviations: IC50, 50% inhibitory concentration; NA, not applicable.
aRefers to the group of organisms that have known activity with the compounds in the collection, as detailed by the MMV.