Figure 3. Instructional examples of bioactive small molecules that bind RNA secondary structures.
Molecules that bind RNA secondary structures (part a) and trinucleotide repeats (part b). Molecules are listed by their quantitative estimate of drug-likeness (QED) score, with the most drug-like molecules towards the top and towards the left if the molecules are on the same row. The equilibrium dissociation constant (Kd) is listed for most molecules; if no Kd was available, the median inhibitory concentration (IC50) is provided instead (indicated by an asterisk). HCV IRES, hepatitis C virus internal ribosome entry site; Kd, equilibrium dissociation constant; pre-miR, pre-microRNA; RRE, Rev response element; TAR, transactivation response.