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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Neurobiol Dis. 2019 Jan 21;125:55–66. doi: 10.1016/j.nbd.2019.01.009

Fig.5. BL-targeted catecholaminergic lesion increases anxiety-like behavior in the light-dark exploration test.

Fig.5

(A) Novel open field. Vehicle- (n=20) and 6-OHDA-injected (n=21) mice showed a similar percentage of time (p=0.74, unpaired t-test) in the aversive center of an open field arena. (B) Marble burying. Vehicle- (n=9) and 6-OHDA-injected (n=12) mice did not differ in the number of marbles buried (p=0.98, Mann Whitney test). Empty circles show the number of marbles buried by each animal. As different mice buried the same number of marbles, some empty circles are superimposed. (C) Light-dark exploration. 6-OHDA-injected animals (n=12) spent significantly less time (p=0.02, unpaired t-test) in the lit compartment of the light-dark exploration test, as compared to vehicle-injected controls (n=9). Box-whisker plots show median values and 25th/75th percentiles with 10th and 90th percentile whiskers; (+) shows the mean value. Empty circles represent values outside the10th and 90th percentiles. *p<0.05, unpaired t test.