Table 1.

Responses of selenogenome expression to dietary Se and fat in pigs¹

Name	Location	< 0.02 mg Se/kg2	0.4 – 3 mg Se/kg2	High Fat Diet
Responding to Only Se
GPX13	Cyto/Mito	H/K/aL/M/Pi/S/aTh↓	H/K/Th↔; aL/aM/aTh↑; Pi/S↓
SELENOP3	EC	K/L/M/Te/Th↓	H/K/L↔; M/Te/Th↑
SELENOS3	ER/Memb	B/K/L/Pi/S/Th↓	B/H/K/L/M↔; Th↑
SELENOT	ER	H/L/M↑	H/L/M↔
SEPHS2	Cyto	L/Th↔; H↑; HT/Pi↓	H/L↔; HT/Pi/Th↓
Responding to Only Fat
DIO2	Memb4			Th↑
GPX6	EC4			M↑
SELENOK	ER/Memb4			Pa↓
Responding to Both Se and Fat
DIO1	Memb	L/Pi/Te/Th↔	M↓	Pa↓
GPX3	EC	aPl/Pi/Te↓	aPl↔; L/M↑	HT↑
MSRB1	Cyto/Nu	S↓	S↓	A↓
SELENOF3	ER	K/Pi/S/Th↓	Pi/S/Te/Th↓	L↑
SELENOH3	Nu	K/L/Pi/S/Th↓	K/Th↔; L↑; S↓	Pa↓
SELENOI3	Memb4	Pi/S/Th↓	Pi/S/Th↓	A/HT/Pa/Pi↓
SELENOM	ER/Gol4	S/Th↓	S↓	A/K↓; Pi↑
SELENOO	Mito4	H/HT↑	H/HT↔	K↑
SELENOV	?	HT/K/M↑; Th↓	HT/K/M↔; Th↓	A/L↓; M↑
SELENOW	Cyto	L↓	L↓	Pa↓
TXNRD1	Cyto/Nu	L↓; Te↔	M/Te↓; L↔	Th↑; HT/Pi↓

¹Abbreviations and arrows: superscript a (^a), enzyme activity of the selenoprotein; Cyto, cytosol; EC, extracellular; ER, endoplasmic reticulum; A, adipose tissue; B, blood; Gol, Golgi apparatus; H, heart; HT, hypothalamus; K, kidney; L, liver; M, muscle; Memb, membrane; Mito, mitochondria; Nu, nucleus; Pa, pancreas; Pl, Plasma; Pi, pituitary; S, spleen; Se, selenium; Te, testes; Th, thyroid;; ↑, increase; ↓, decrease; ↔, no differences.

²Compared with 0.1 – 0.3 mg Se/kg diet.

³Changed in many tissues

⁴Supported by the database of uniprot (http://www.uniprot.org/uniprot/).