Table 2.

Responses of selenogenome expression to dietary Se and fat in rodents¹

Name	Location	Se Deficiency2	1 mg Se/kg2	3 – 5 mg Se/kg2	High Fat Diet
Responding to Only Se
Dio1	Memb	A↔	A↓	A↔
aGpx1	Cyto/Mito	L↓	L↓	L↑
Selenow	Cyto	L↓	L↓	L↔
Txnrd1	Cyto/Nu	L↓	L↔	L↔
Txnrd2	Cyto	L↓	L↔	L↔
Txnrd3	Mito	L↓	L↔	L↔
Gpx3	EC	aPl/L↓	aPl/L↑	aPl/L↔
Selenot	ER	L↓
Responding to Both Se and Fat
Dio2	ER		A/L↓		L↑
Selenof	ER		A↓; L↑		A/L↑
Selenok	ER		A↓		A↓
Selenom	ER		A/L↓		A↓; L↑
Selenos	ER	M↓		L↑	A↓; L↑
Gpx4	Cyto/Nu/Mito	L↓	A↓		A↓
Msrb1	Cyto/Nu	aL↓	A↓	L↔	L↑
Selenoh	Nu	L↓	A↓	L↑	A↓; L↑
Dio3	Memb		A↓		A/L↑
Selenoi	Memb3		A↓		A↓; L↑
Gpx6	EC3		A↓		A↓; L↑
Selenop	EC				A↑

¹Abbreviations and arrows: superscript a (^a), enzyme activity of the selenoprotein; Cyto, cytosol; EC, extracellular, ER, endoplasmic reticulum; A, adipose tissue; Memb, membrane; Mito, mitochondria; Nu, nucleus; Pl, Plasma; Se, selenium; ↑, increase; ↓, decrease; ↔, no differences.

²Compared with 0.1 – 0.3 mg Se/kg diet.

³Supported by the database of uniprot (http://www.uniprot.org/uniprot/).