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Effect of hypoxia on glucose metabolism. (A) Conversion efficiency of glucose to lactate in 4T1/Cas9, 4T1/PKM-KO, 4T1/KO+hPKM1 and 4T1/KO+hPKM2 cells under normoxia and hypoxia. (B) Glucose kept for intracellular utilization other than lactate production in 4T1/Cas9, 4T1/PKM-KO, 4T1/KO+hPKM1 and 4T1/KO+hPKM2 cells under normoxia and hypoxia.
