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. 2018 Nov;15(4):389–399. doi: 10.20892/j.issn.2095-3941.2018.0122

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Copyright 2017 Cancer Biology & Medicine

This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Tumor images of 4T1/Cas9, 4T1/PKM-KO, 4T1/KO+hPKM1 and 4T1/KO+hPKM2 cells inoculated in BALB/c mice for 26 days. # indicates tumors used for immunohistochemistry staining. (B) Staining of 4T1/Cas9, 4T1/PKM-KO, 4T1/KO+hPKM1 and 4T1/KO+hPKM2 tumors for PKM2 or PKM1. High-power micrographs of the same tumors were shown in the right. — PKM is differentially expressed in tumors.