Table 2.
Sequence polymorphisms and summary statistics of the near full-length Pvmdr1 gene in different populations*.
| Population | No. isolates | Polymorphic sites | Singletons | Amino acid changes* | Syn | Non-syn | π ± SD | Haplotypes |
||
|---|---|---|---|---|---|---|---|---|---|---|
| H | Hd ± SD | |||||||||
| Thailand (this study) | 88 | 34 | 19 | 15 | 13 | 21 | 0.00085 ± 0.00005 | 48 | 0.961 ± 0.011 | |
| Tak | 22 | 15 | 7 | 9 | 6 | 9 | 0.00073 ± 0.00008 | 17 | 0.961 ± 0.029 | |
| Kanchanaburi | 37 | 26 | 14 | 12 | 10 | 16 | 0.00090 ± 0.00007 | 27 | 0.961 ± 0.022 | |
| Ubon Ratchathani | 30 | 14 | 6 | 8 | 7 | 7 | 0.00072 ± 0.00083 | 16 | 0.927 ± 0.025 | |
| Thailand (plasmodb) | 13 | 5 | 4 | 1 | 1 | 4 | 0.00025 ± 0.00007 | 5 | 0.692 ± 0.110 | |
| China | 7 | 10 | 8 | 2 | 3 | 7 | 0.00075 ± 0.00018 | 6 | 0.952 ± 0.096 | |
| PNG | 7 | 1 | 0 | 1 | 0 | 1 | 0.00014 ± 0.0003 | 2 | 0.571 ± 0.110 | |
| India | 2 | 4 | 4 | 0 | 3 | 1 | 0.00091 ± 0.00046 | 2 | 1.000 ± 0.500 | |
| Madagascar | 8 | 14 | 10 | 4 | 4 | 10 | 0.00110 ± 0.00023 | 8 | 1.000 ± 0.063 | |
| Mexico | 15 | 7 | 6 | 1 | 3 | 4 | 0.00024 ± 0.00013 | 4 | 0.371 ± 0.153 | |
| Peru | 30 | 8 | 4 | 4 | 2 | 6 | 0.00032 ± 0.00007 | 7 | 0.692 ± 0.057 | |
| Brazil | 5 | 4 | 4 | 0 | 2 | 2 | 0.00038 ± 0.00011 | 4 | 0.900 ± 0.161 | |
| Colombia | 22 | 63 | 59 | 4 | 24 | 39 | 0.00161 ± 0.00108 | 7 | 0.814 ± 0.049 | |
| Other | 4 | 9 | 8 | 1 | 2 | 7 | 0.00111 ± 0.00026 | 4 | 1.000 ± 0.177 | |
| Global | 201 | 46 | 30 | 16 | 14 | 30 | 0.00069 ± 0.00004 | 53 | 0.907± 0.013 | |
*
For amino acid changes, only the parsimony-informative changes are included here. Syn, synonymous changes; non-syn, nonsynonymous changes; H, number of haplotypes; Hd, haplotype diversity; SD, standard deviation.