Figure 2. Associations between the expression of MTND1 and rs2304694 in whole blood data.

(A) Genome-wide association analysis for the expression of MTND1 in whole blood data from the discovery datasets (meta-analysis of CARTaGENE, TwinsUK and GTEx data), (B) Genome-wide association analysis for the expression of MTND1 in whole blood data from the replication dataset (NIMH data), (C) Expression of MTND1 (Log₁₀(TPM +1)) versus non-reference allele frequency of rs2304694 in the four independent whole blood datasets.

Figure 2—figure supplement 1. QQ plots for associations between nuclear genetic variants and mitochondrial gene expression for discovery associations that replicate at the nominal 5% level.