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. 2019 Feb 18;8:e41927. doi: 10.7554/eLife.41927

Figure 3. Replication and validation of significant associations between nuclear genetic variants and the expression of mitochondria-encoded genes.

Figure 3.

(A) Discovery versus replication beta estimates for significant associations between nuclear genetic variation and mitochondrial gene expression detected in discovery data at FDR 5%, (B) Validation of the association between rs2304694 and the expression of MTND4 using quantitative PCR in LCLs. MTND4 mRNA expression levels are normalised to GAPDH (theoretical quantities).