Figure 2.

For visualization purposes of inverse age x group interactions of centromedial (CM) amygdala connectivity, we calculated least squared means for amygdala connectivity values at ages 10, 18, and 25 years for typically developing youth (blue), psychosis spectrum youth (red), and youth with other psychopathology (grey). A) In comparison to typically developing youth, psychosis spectrum youth exhibited reduced CM amygdala-ventrolateral prefrontal connectivity during late childhood/early adolescence, and increased connectivity during adulthood. B) In comparison to typically developing youth, psychosis spectrum youth exhibited increased CM amygdala-dorsolateral prefrontal connectivity during late childhood/early adolescence. C) In comparison to typically developing youth, psychosis spectrum youth exhibited reduced CM amygdala-thalamus connectivity during late childhood/early adolescence. D) In comparison to typically developing youth and youth with other psychopathology, psychosis spectrum youth exhibited reduced CM amygdala-putamen connectivity during late childhood/early adolescence. Psychosis spectrum youth exhibited greater connectivity between these two regions during adulthood. E) A similar pattern of developmental disruption was observed between CM amygdala-caudate connectivity. F) Psychosis spectrum youth exhibited reduced CM amygdala-occipital cortex connectivity when compared to typically developing youth and youth with other psychopathology.