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. Author manuscript; available in PMC: 2019 Mar 15.
Published in final edited form as: Cell Rep. 2019 Jan 29;26(5):1189–1202.e6. doi: 10.1016/j.celrep.2019.01.028

Figure 7. Metabolomics Analysis Reveals Altered Tryptophan Metabolism in SCA7 Patients.

Figure 7.

(A–F) We performed high-resolution mass spectrometry in combination with liquid chromatography (LC-HRMS) on plasma samples from 13 fasted SCA7 patients and 35 fasted controls. Depicted are boxplot representations for analyte signal areas in log-10, corresponding to (A) tryptophan, (B) kynurenine, (C) kynurenine/tryptophan ratio, (D) 5-hydroxytryptophan, (E) kynurenic acid, and (F) xanthurenic acid. **p < 0.01 and ***p < 0.001 (two-tailed t test). Error bars indicate SEM.