Figure 7. Abn-CBD protects against acute light-induced retinal degeneration in Balb/cJ mice.

(a) Schematic representation of the experimental design. (b) Representative OCT images of the retinas for Balb/cJ mice not exposed to light (top) and animals pretreated with DMSO (vehicle) or abn-CBD (30 mg kg⁻¹) and subjected to strong illumination (middle and bottom, respectively). The images indicate the protective effect of abn-CBD on photoreceptor cells. ONL, outer nuclear layer; INL, inner nuclear layer. Bars indicate 100 μm. (c) Quantification of the changes in the retinal morphology based on the thickness of the ONL of the OCT images (n = 6). The retinal morphology was preserved by the CRBP1 inhibitor in a dose-dependent manner. (d) Representative retinal images of the inferior retina of Balb/cJ mice after light exposure. Severe retinal degeneration is observed 7 d post illumination in untreated mice, whereas systemic administration of abn-CBD resulted in partial preservation of the photoreceptor cells as compared to the eyes not exposed to light. OS, photoreceptor outer segments, IS, photoreceptor inner segments, OPL, outer plexiform layer; IPL, inner plexiform layer; GCL, ganglion cell layer. Bars indicate 50 μm.