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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Traffic. 2019 Feb 28;20(4):295–300. doi: 10.1111/tra.12636

Figure 1:

Figure 1:

Differences in mechanistic understanding of clathrin independent endocytosis (CIE) and clathrin mediated endocytosis (CME). CME has a well characterized mechanism with numerous components and their roles identified. AP2 subunits bind to motifs on CME cargo, they recruit clathrin which then helps to form a well-defined coat on the endosomes, dynamin then helps mediate scission of these endosomes. In contrast, there is little known about the machinery that drives CIE. Galectins and glycan interactions could serve as an extracellular coat and play a role in mediating CIE from the lumenal side of these endosomes.