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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Breast Cancer Res Treat. 2018 Nov 17;174(1):227–235. doi: 10.1007/s10549-018-5048-8

Table 3.

Incidence of a second event by treatment group and time since diagnosis among 1,252 DCIS cases from the Vermont Breast Cancer Surveillance System.

Time Since Diagnosis
0–5 years 5–10 years >10 years
Annual Incidence (%) 95% Cl Annual Incidence (%) 95% Cl Annual Incidence (%) 95% Cl Ptrenda Pinteractionb
BCS alone 3.1 2.2 – 4.2 3.3 2.1 – 4.9 1.7 0.7 – 3.5 0.11 Ref
BCS + RT 1.8 1.1 – 2.6 2.0 1.2 – 3.2 2.8 1.6 – 4.7 0.20 0.04
BCS + RT and ET 0.7 0.3 – 1.3 1.2 0.6 – 4.4 2.1 0.8 – 4.4 0.03 0.01
BCS + ET 1.4 0.6 – 2.8 0.9 0.2 – 2.6 1.2 0.2 – 4.4 0.97 0.57
Ipsilateral mastectomy 1.4 0.7 – 2.4 1.9 0.8 – 3.4 0.6 0.1 – 2.2 0.41 0.93

Abbreviations: BCS, breast conserving surgery; DCIS, ductal carcinoma in situ; ET, endocrine therapy; RT, radiation therapy.

a

Test for trend in annual incidence across three categories of follow-up time intervals.

b

Test for treatment by time since DCIS diagnosis interaction to assess differences in trend compared to BCS alone as reference group.