Fig. 6.

AFM imaging of the α-synuclein (a-c) and Aβ (d-f) fibrillisation process [57]. Imaging of the amyloid fibril formation via AFM enabled to compare aggregation process of α-synuclein and Aβ. During the initial stages of aggregation Aβ formed oligomeric species (d), while α-synuclein remained mainly in the monomeric form (a). At later stages of aggregation fibrillary (b) and protofibrillar (e) species were observed for α-synuclein and Aβ respectively. Mature amyloid fibrils were detected for both proteins at the late stages of aggregation (c, f).