Fig. 3.

LTD could not be induced using a 1 Hz stimulation paradigm in either WT or rTg4510 PRh slices. The graph depicts the pooled data from 5 WT and 5 rTg4510 slices showing the response to 900 stimuli delivered at 1 Hz (represented by the black bar). No significant LTD (1 h post stimulation) was induced in either genotype (P > 0.05, paired 2-sample t tests in both groups). Furthermore, there was no significant difference in the post-stimulation baseline normalised fEPSP amplitudes between WT and rTg4510 mice (P = 0.5, unpaired 2 sample t test). Inset traces are averages of 4 consecutive synaptic responses from an example experiment in both groups, taken from the time points indicated on the graph