Fig. 4.

Functional annotation (eQTLs and chromatin-state in brain tissues) of the genomic region in the vicinity of variant rs864736 [with FUMA (Watanabe et al. 2017)]. Brain tissues names: E054: Ganglion Eminence derived primary cultured neurospheres, E053: Cortex derived primary cultured neurospheres, E071: Brain Hippocampus Middle, E074: Brain Substantia Nigra, E068: Brain Anterior Caudate, E069: Brain Cingulate Gyrus, E072: Brain Inferior Temporal Lobe, E067: Brain Angular Gyrus, E073: Brain Dorsolateral Prefrontal Cortex, E070: Brain Germinal Matrix, E082: Fetal Brain Female, E081: Fetal Brain Male, E125: Astrocytes Primary Cells. RoadMap Core 15 chromatin state model: TssA active transcription start site (TSS), TssFlnk flanking active TSS, TxFlnk transcription at gene 5′ and 3′, Tx strong transcription, TxWk weak transcription, EnhG genic enhancers, Enh enhancers, ZNF/Rpts ZNF genes & repeats, Het heterochromatin, TssBiv bivalent/poised TSS, BivFlnk flanking bivalent TSS/enhancer, EnhBiv bivalent enhancer, ReprPC repressed polycomb, ReprPCWk weak repressed polycomb, Quies quiescent/low